SIGNIFICANCE OF ALDOSTERONE-SYNTHESIS GENE POLYMORPHISM IN THE DEVELOPMENT OF FIBROSIS PROCESSES IN CARDIORENAL SYNDROME DEVELOPED ON THE BASIS OF CHRONIC HEART FAILURE

Authors

  • Mrfuzayl B. Sayfullaev Researcher Tashkent Medical Academy, Uzbekistan
  • Abdigaffar G. Gadaev Researcher, Tashkent Medical Academy, Uzbekistan
  • Rustam I. Turakulov Researcher, Tashkent Medical Academy, Uzbekistan
  • Oybek Z. Abdukholikov Researcher, Tashkent Medical Academy, Uzbekistan

Keywords:

chronic heart failure, cardiorenal syndrome, aldosterone

Abstract

In this article, the importance of aldosterone-synthesis gene polymorphism in the development of fibrosis processes in cardiorenal syndrome developed on the basis of chronic heart failure is studied. The obtained results showed that the C344T polymorphism of the CYP11B2 gene in chronic heart failure is consistent with the TT genotype and the occurrence of cardiorenal syndrome as a result of the T allele, and the TT genotype is consistent with the severe course of the disease. Based on different hemodynamic types of CHF, in patients with advanced cardiorenal syndrome, CYP11B2 gene C344T polymorphism carriers of the SS genotype had lower serum aldoterone levels than patients with ST and TT genotypes.

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References

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Published

2023-01-30

How to Cite

Mrfuzayl B. Sayfullaev, Abdigaffar G. Gadaev, Rustam I. Turakulov, & Oybek Z. Abdukholikov. (2023). SIGNIFICANCE OF ALDOSTERONE-SYNTHESIS GENE POLYMORPHISM IN THE DEVELOPMENT OF FIBROSIS PROCESSES IN CARDIORENAL SYNDROME DEVELOPED ON THE BASIS OF CHRONIC HEART FAILURE. International Scientific and Current Research Conferences, 1(01), 99–109. Retrieved from https://orientalpublication.com/index.php/iscrc/article/view/869

Issue

RESULTS OF MODERN SCIENTIFIC RESEARCH

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Articles

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Copyright (c) 2023 Mrfuzayl B. Sayfullaev, Abdigaffar G. Gadaev, Rustam I. Turakulov, Oybek Z. Abdukholikov

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