INFLUENCE OF EMODIN ON COAGULATION HEMOSTASIS

Section: Articles Published Date: 2023-03-20 Pages: 89-92 Conference Proceedings Volume: VITAL ISSUES OF MODERN SCIENTIFIC RESEARCH

Authors

  • Khoshimov N.N. nstitute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Nasirov K.E. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Ortikov M.M. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Dedaboev J.I. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Akhtamov M.A. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Khodjiev S.S. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Kozokov I.B. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Abdurakhmonov Zh.A Institute Of Bioorganic Chemistry Named After Academician A.S.Sadikov, Tashkent, Uzbekistan
  • Mukhtorov A.A. Namangan State University, Uzbekistan
  • Mamadaminov R.R. Namangan State University, Uzbekistan
  • Eshbakova K.A. Institute Of Chemistry Of Plant Substances. Tashkent, Uzbekistan
PDF

Abstract

The alkaloid emodin was studied in coagulation hemostasis of blood in rats in vitro. The results show that Emodin prolongs prothrombin time and aPTT more effectively, but does not affect thrombin time. At the same time, prothrombin time and APTT were prolonged up to a certain dose (50 µg/ml). These results may indicate the inhibition of one of the factors II, V, VII, and X of coagulation hemostasis.

Keywords

Alkaloid, activated partial thromboplastin time (APTT), prothrombin time