THE ROLE OF CIRCULATING IMMUNE COMPLEXES IN CHILDREN WITH EPIDERMOLYSIS BULLOSA

Authors

  • A.A. Ismailova Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
  • T.U. Aripova Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
  • I.U. Khamraeva Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
  • Sh.Z. Khabibullaev Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
  • S.A. Ubaydullaev Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan

Abstract

Systemic inflammation is considered a key factor in the immunopathogenesis of epidermolysis bullosa (EB); however, this has been described only in small and heterogeneous cohorts. The systemic nature of inflammation in EB has been confirmed by numerous studies. Circulating immune complexes (CICs) are antigen–antibody complexes that form in the bloodstream and circulate throughout the vascular system. It is known that CICs can activate the complement system, leading to the destruction of bacteria, viruses, and even host antigens. These complexes can also be phagocytosed by monocytes and macrophages, which are responsible for clearing CICs from the circulation. Based on this rationale, we analyzed serum CIC levels in children with EB to evaluate their concentrations and the inflammatory significance of these immunological markers.

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Published

2025-04-30

How to Cite

A.A. Ismailova, T.U. Aripova, I.U. Khamraeva, Sh.Z. Khabibullaev, & S.A. Ubaydullaev. (2025). THE ROLE OF CIRCULATING IMMUNE COMPLEXES IN CHILDREN WITH EPIDERMOLYSIS BULLOSA. International Scientific and Current Research Conferences, 1(01), 238–239. Retrieved from https://orientalpublication.com/index.php/iscrc/article/view/1881

Issue

2025: ADVANCING SOCIAL JUSTICE: STRATEGIES FOR EQUITY AND INCLUSION

Section

Articles

License

Copyright (c) 2025 A.A. Ismailova, T.U. Aripova, I.U. Khamraeva, Sh.Z. Khabibullaev, S.A. Ubaydullaev

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